Metformin 500 mg, 850 mg, 1000 mg – Dosage Guide, Benefits & Comparison
Table of Contents
What is Metformin?
Metformin is a first-line oral medication used to manage type 2 diabetes mellitus. It belongs to the class of drugs known as biguanides and helps lower blood sugar levels by improving insulin sensitivity and decreasing glucose production in the liver.
Uses of Metformin
Metformin is prescribed for:
- 🩸 Type 2 Diabetes – to control high blood sugar
- ⚖️ Polycystic Ovary Syndrome (PCOS) – to improve insulin resistance
- 📉 Weight loss support in insulin-resistant individuals
- 🧬 Prediabetes or metabolic syndrome
Metformin Dosage Options
Metformin is available in different strengths depending on your condition and how your body responds:
- Metformin 500 mg: Common starting dose
- Metformin 850 mg: Intermediate dose
- Metformin 1000 mg: Often used in extended-release formulas for once/twice daily use
All dosages may be prescribed as immediate-release (IR) or extended-release (XR/ER) based on patient tolerance.
Metformin 500 mg vs 850 mg vs 1000 mg
| Dosage | Use Case | Frequency | Common Form |
|---|---|---|---|
| Metformin 500 mg | Starting dose for new patients | 2–3 times daily | Immediate Release |
| Metformin 850 mg | Intermediate control, step-up therapy | 1–2 times daily | Immediate or Extended Release |
| Metformin 1000 mg | Maintenance dose for well-controlled patients | 1–2 times daily | Extended Release |
Max daily dose: 2000–2550 mg depending on formulation and doctor’s prescription.
Possible Side Effects of Metformin
- 🌀 Nausea or vomiting (common at start)
- 💨 Gas, bloating or mild diarrhea
- 🛌 Lethargy with overdose or in kidney issues
- ⚠️ Rare: Lactic acidosis (emergency – seek help)
Taking Metformin with food helps reduce GI side effects.
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FAQs – Metformin Dosage Guide
Which Metformin dose is right for me?
Doctors usually start with Metformin 500 mg and adjust upward based on your blood sugar control and side effects.
Is 1000 mg of Metformin too much?
No, 1000 mg is a standard single dose. However, the total daily dose should not exceed 2000–2550 mg unless specifically prescribed.
Can I switch from 500 mg to 1000 mg directly?
Usually, doctors increase the dose gradually to reduce side effects. Never switch doses without medical advice.
Should I take Metformin with food?
Yes. Taking Metformin with meals helps reduce stomach upset and improves absorption.