Description
Metformin 500 mg – Trusted First-Line Treatment for Type 2 Diabetes
Metformin 500 mg is a widely used oral antidiabetic medication that plays a vital role in the management of Type 2 diabetes mellitus. It belongs to a class of medications known as biguanides, which lower blood glucose levels by improving insulin sensitivity, decreasing hepatic glucose production, and increasing peripheral glucose uptake.
This lower-dose option is ideal for initiating therapy or for individuals who require a more gradual dose adjustment due to sensitivity or gastrointestinal side effects. Metformin 500 mg helps patients maintain balanced blood sugar levels and reduce the long-term risks of diabetes-related complications.
What Is Metformin 500 mg Used For?
- Primary treatment for Type 2 diabetes
- Used alone or in combination with other antidiabetic medications
- Helps reduce insulin resistance in PCOS (polycystic ovary syndrome)
- Supports weight and cholesterol management in diabetic patients
How Metformin Works
Metformin works through three main mechanisms:
- Inhibits liver glucose production (gluconeogenesis)
- Increases insulin sensitivity in peripheral tissues like muscle and fat
- Reduces glucose absorption from the intestines
It does not cause hypoglycemia when used alone, making it safer than sulfonylureas or insulin in monotherapy.
Key Benefits of Metformin 500 mg:
- Clinically proven to lower fasting and post-meal blood sugar
- Weight-neutral or may support mild weight loss
- Improves lipid profile and cardiovascular outcomes
- Available in immediate-release and extended-release forms
- Minimal risk of hypoglycemia
Dosage & Administration
- Recommended starting dose: 500 mg once or twice daily with meals
- Take with food to reduce nausea and GI discomfort
- Dose may be increased gradually based on tolerance and glucose targets
- Do not crush extended-release tablets
Possible Side Effects
Most common side effects are gastrointestinal in nature and often resolve with continued use:
- Nausea
- Diarrhea
- Abdominal bloating or cramping
- Metallic taste in mouth
Rare but serious: Lactic acidosis—a medical emergency requiring immediate attention.
Precautions
- Not suitable for patients with significant kidney or liver disease
- Use caution in the elderly or those undergoing radiological procedures
- Limit alcohol consumption
- Regular blood sugar and kidney function monitoring is recommended
Storage Information
- Store below 25°C in a dry place
- Protect from moisture and direct sunlight
- Keep out of reach of children
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Frequently Asked Questions
What is Metformin 500 mg used for?
It is used to treat Type 2 diabetes by improving insulin sensitivity and lowering blood sugar levels.
How should I take Metformin 500 mg?
Take it once or twice daily with meals to reduce side effects like nausea or stomach upset.
Is Metformin 500 mg safe for long-term use?
Yes, it is commonly prescribed for long-term diabetes management with regular kidney monitoring.
Does Metformin cause hypoglycemia?
No, Metformin alone does not typically cause low blood sugar unless combined with insulin or other drugs.
Can I take Metformin for weight loss?
While not a weight loss drug, Metformin may help reduce appetite and support weight management in diabetic patients.
