Flutamide 250 mg: Antiandrogen Therapy for Prostate Cancer
Table of Contents
What is Flutamide 250 mg?
Flutamide 250 mg is an oral antiandrogen medication used primarily in the treatment of advanced prostate cancer. It works by blocking the action of male hormones (androgens), such as testosterone, which can stimulate the growth of prostate cancer cells.
How Flutamide 250 mg Works
Flutamide belongs to a class of drugs called nonsteroidal antiandrogens. It competes with testosterone and dihydrotestosterone (DHT) for binding to androgen receptors in prostate cells. By inhibiting these hormones, Flutamide 250 mg slows or stops the growth of hormone-sensitive prostate cancer.
Uses of Flutamide 250 mg
Flutamide 250 mg is used in combination with a luteinizing hormone-releasing hormone (LHRH) agonist as part of hormone therapy for:
- Advanced Prostate Cancer – to slow tumor progression
- Metastatic Prostate Cancer – to manage symptoms and reduce tumor size
- Adjunct to surgical or radiation therapy – to prevent recurrence
Flutamide 250 mg Dosage
The standard recommended dosage for Flutamide 250 mg is:
- Adults: 250 mg orally three times daily (every 8 hours)
- Total Daily Dose: 750 mg per day
This dosage is often combined with an LHRH analog for a more complete androgen blockade.
Administration Tips
- Take Flutamide 250 mg with or without food
- Swallow tablets whole with water
- Do not skip doses—maintain consistent hormone suppression
Side Effects of Flutamide 250 mg
Common side effects of Flutamide 250 mg may include:
- Hot flashes
- Loss of libido
- Gynecomastia (breast enlargement)
- Diarrhea
- Nausea
Serious Adverse Effects
- Liver toxicity – monitor liver enzymes regularly
- Shortness of breath or chest pain
- Hematuria (blood in urine)
Note: Liver function tests should be performed before and during treatment with Flutamide 250 mg due to the risk of hepatotoxicity.
Precautions and Warnings
Before using Flutamide 250 mg, inform your doctor if you have:
- Liver disease
- History of cardiovascular problems
- Diabetes or glucose intolerance
This medication is for male use only and should not be used by women, children, or during pregnancy.
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FAQs About Flutamide 250 mg
Is Flutamide 250 mg a chemotherapy drug?
No, Flutamide is a hormonal therapy (antiandrogen), not a traditional chemotherapy drug.
How long should I take Flutamide 250 mg?
The duration depends on your cancer stage and response to treatment. It is usually part of long-term therapy under medical supervision.
Can Flutamide 250 mg cause infertility?
Yes, long-term use can affect fertility by reducing testosterone levels.
Does Flutamide affect PSA levels?
Yes, it can lower PSA levels, which is a good sign of response in prostate cancer treatment.
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