Description

Flutamide 250 mg – Androgen Blocker for Prostate Cancer Treatment

Flutamide 250 mg is a prescription medication used in the treatment of advanced prostate cancer. As a non-steroidal anti-androgen, it works by blocking the action of androgens (male hormones) in the body, which are responsible for stimulating the growth of prostate cancer cells. Flutamide is typically used in combination with other hormone therapies, such as a luteinizing hormone-releasing hormone (LHRH) agonist.

What is Flutamide 250 mg Used For?

Flutamide is primarily prescribed for:

• Advanced prostate cancer – in combination with surgical or medical castration
• Palliative treatment – to reduce symptoms and slow cancer progression

Flutamide does not cure prostate cancer but helps to manage the condition by reducing androgen stimulation of cancer cells, thereby slowing tumor growth and easing symptoms such as pain or urinary difficulty.

How Does Flutamide Work?

Flutamide is a potent anti-androgen medication that competes with testosterone and dihydrotestosterone (DHT) for binding to androgen receptors in prostate cells. By preventing these hormones from attaching to the cancer cells, it stops them from growing and dividing. It’s most effective when used with a GnRH agonist or after an orchiectomy (surgical removal of the testes).

Key Benefits

• Slows the progression of prostate cancer
• Reduces prostate tumor size and associated symptoms
• Improves quality of life in advanced cancer patients
• Oral medication — easy to administer

Flutamide 250 mg Dosage and Administration

The standard adult dose is 250 mg taken three times a day, approximately every 8 hours, with or without food. It should be taken consistently as directed by a healthcare provider. Flutamide is often started alongside a GnRH analog to avoid initial testosterone surge symptoms (flare-up).

• Typical dosage: 250 mg every 8 hours
• Missed dose: Take as soon as remembered, unless it’s near the next dose time
• Do not: Double the dose to make up for a missed one

Possible Side Effects of Flutamide

As with any medication, Flutamide may cause side effects. Patients should be monitored regularly for liver function and general tolerance.

• Breast tenderness or enlargement (gynecomastia)
• Hot flashes
• Loss of libido or impotence
• Fatigue and weakness
• Diarrhea
• Hepatotoxicity (liver damage) – monitor liver enzymes regularly

Warnings and Precautions

Flutamide should be used with caution and under close medical supervision. Inform your doctor if you:

• Have liver disease or abnormal liver function tests
• Have any history of cardiovascular problems
• Are taking other hormone therapies
• Experience signs of liver damage (e.g., yellowing of the skin, dark urine)

Flutamide is not intended for use in women or children and is strictly for male patients with prostate cancer.

Drug Interactions

Tell your doctor if you’re taking any of the following:

• Warfarin or other anticoagulants
• Liver enzyme-affecting drugs
• Alcohol (increases risk of liver toxicity)

Storage Instructions

• Store at room temperature (15°C – 30°C)
• Protect from moisture and heat
• Keep out of reach of children

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Conclusion

Flutamide 250 mg is a key component in hormone therapy for advanced prostate cancer. By blocking androgen receptors, it helps control disease progression and improve patient outcomes. Regular medical supervision is essential for safe and effective use.