Ceritinib 150 mg: Targeted Therapy for ALK-Positive Non-Small Cell Lung Cancer (NSCLC)
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What is Ceritinib 150 mg?
Ceritinib 150 mg is a prescription medication used for the treatment of ALK-positive non-small cell lung cancer (NSCLC). It is an oral tyrosine kinase inhibitor (TKI) that targets abnormal anaplastic lymphoma kinase (ALK) proteins responsible for cancer growth and progression.
Ceritinib is often used when cancer has spread to other parts of the body or when the patient has not responded well to previous therapies. It is marketed under the brand name Zykadia.
How Ceritinib Works
Ceritinib is a selective ALK inhibitor. It binds to and inhibits ALK, a gene that produces proteins involved in cell growth. In ALK-positive cancers, this gene is abnormally activated. Ceritinib helps to block this faulty signal, slowing the spread of cancer and sometimes shrinking the tumors.
Who Should Use Ceritinib?
Ceritinib 150 mg is recommended for:
- Patients diagnosed with ALK-positive metastatic NSCLC
- Patients who have progressed on or are intolerant to Crizotinib (Xalkori)
- Adults only – not approved for pediatric use
ALK-positive status must be confirmed through an FDA-approved diagnostic test before starting treatment.
Recommended Dosage
Standard adult dose: 750 mg once daily on an empty stomach.
- This is equivalent to 5 tablets of Ceritinib 150 mg.
- Take at least 1 hour before or 2 hours after a meal.
- Do not split or crush the tablets.
- If a dose is missed, take it as soon as you remember. If it’s close to the next dose, skip it.
Dose adjustments may be necessary based on liver function or side effect severity. Always follow your oncologist’s advice.
Potential Side Effects
Common side effects of Ceritinib 150 mg include:
- Nausea and vomiting
- Diarrhea
- Fatigue
- Abdominal pain
- Elevated liver enzymes
- Loss of appetite
Serious but rare side effects:
- QT prolongation (irregular heart rhythm)
- Severe liver damage
- Pancreatitis
- Interstitial lung disease
Routine monitoring through blood tests, ECG, and liver function panels is essential during treatment.
Precautions & Warnings
- Not to be used during pregnancy or breastfeeding – may harm the fetus or infant.
- Use effective contraception during treatment and for several weeks after the last dose.
- Inform your doctor about any pre-existing heart, liver, or digestive conditions.
- Avoid grapefruit or grapefruit juice while on Ceritinib, as it may increase the drug’s toxicity.
Where to Buy Ceritinib 150 mg Online
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Frequently Asked Questions
Is Ceritinib a chemotherapy drug?
No, Ceritinib is a targeted therapy, not traditional chemotherapy. It specifically blocks the activity of ALK proteins in ALK-positive NSCLC.
How long can I take Ceritinib?
You may continue taking Ceritinib as long as you are tolerating it well and your cancer is not progressing. Treatment duration varies by patient response.
Can Ceritinib cure lung cancer?
Ceritinib does not cure lung cancer, but it can significantly slow disease progression, shrink tumors, and improve quality of life in ALK-positive patients.
Are there alternatives to Ceritinib?
Yes, other ALK inhibitors include Crizotinib, Alectinib, Brigatinib, and Lorlatinib. Your oncologist will decide based on your treatment history and response.
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