Description
Afatinib 40 mg – Targeted Treatment for EGFR-Positive Lung Cancer
Afatinib 40 mg is a second-generation tyrosine kinase inhibitor (TKI) used in the first-line treatment of metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. As the standard starting dose, Afatinib 40 mg is widely prescribed for its irreversible inhibition of multiple growth factor receptors involved in cancer progression.
What Is Afatinib 40 mg?
Afatinib 40 mg tablets are a prescription oral therapy developed for adults diagnosed with EGFR mutation-positive NSCLC. It is the recommended starting dose and may be adjusted based on patient tolerance. Afatinib is marketed under the brand name Gilotrif in many countries and is approved by regulatory authorities such as the FDA and EMA.
Afatinib is not chemotherapy—it is a targeted treatment that inhibits the specific molecular pathways driving tumor growth.
How Afatinib Works
Afatinib 40 mg blocks the tyrosine kinase activity of EGFR, HER2, and other members of the ErbB receptor family. These proteins are involved in signaling pathways that control cell growth and division. In cancers with EGFR mutations, these pathways are overactive, leading to uncontrolled tumor development.
Afatinib works by permanently binding to these receptors, thereby shutting down the abnormal signaling and slowing the progression of the cancer.
Benefits of Afatinib 40 mg
- First-line therapy for EGFR-positive NSCLC
- Improves progression-free survival
- Reduces tumor size and delays metastasis
- Oral dosing – no intravenous chemotherapy required
- Can be dose-adjusted to 30 mg or 20 mg if needed
Patients taking Afatinib have reported improved quality of life and longer time before disease progression compared to traditional chemotherapy.
How to Use Afatinib 40 mg
The typical dose is one Afatinib 40 mg tablet taken orally once a day. Your doctor may adjust the dosage depending on your individual health status and treatment response.
Important Instructions:
- Take on an empty stomach (at least 1 hour before or 2 hours after eating)
- Swallow the tablet whole with water—do not crush or chew
- Take at the same time daily for best results
If you miss a dose and it’s been more than 12 hours, skip the dose and continue with the next scheduled one.
Side Effects and Warnings
While effective, Afatinib 40 mg may cause side effects. Most are manageable and decrease with dose adjustment or supportive care.
Common Side Effects:
- Diarrhea
- Skin rash
- Stomatitis (mouth sores)
- Nail inflammation
- Fatigue
Precautions:
- Inform your doctor about any pre-existing liver, lung, or kidney conditions
- Avoid pregnancy while using Afatinib
- Routine lab monitoring is advised during treatment
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