Description
Tolvaptan Tablets 15mg – Treatment for Hyponatremia & ADPKD
Tolvaptan Tablets 15mg is a selective vasopressin V2-receptor antagonist used for treating clinically significant hyponatremia (low blood sodium levels) and slowing the progression of autosomal dominant polycystic kidney disease (ADPKD). Manufactured by leading pharmaceutical companies, Tolvaptan offers targeted treatment by promoting water excretion without affecting electrolyte levels.
This oral medication is particularly effective in patients with SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion), chronic liver disease, and ADPKD. Tolvaptan helps restore serum sodium levels and delays kidney function decline in eligible patients.
What Is Tolvaptan 15mg Used For?
Tolvaptan 15mg is prescribed for:
- Clinically significant hyponatremia caused by SIADH
- Polycystic kidney disease (ADPKD) to slow cyst development and kidney failure progression
- Chronic liver disease-related fluid retention (off-label use in some cases)
How Does Tolvaptan Work?
Tolvaptan is a selective vasopressin V2 receptor blocker that acts on the kidneys to reduce water reabsorption in the collecting ducts. It increases aquaresis—the excretion of free water—thereby correcting low sodium levels and reducing kidney cyst growth in ADPKD patients.
Key Benefits of Tolvaptan Tablets 15mg
- Improves low sodium levels without affecting potassium or other electrolytes
- Slows kidney enlargement in patients with polycystic kidney disease
- Helps manage fluid overload in SIADH and liver conditions
- Convenient once-daily oral administration
Recommended Dosage
The typical starting dose of Tolvaptan is 15 mg once daily. Depending on patient response and medical evaluation, the dosage may be increased gradually. It is best taken during the day to avoid excessive nighttime urination.
Administration Tips:
- Take the tablet with or without food
- Stay well-hydrated during treatment
- Avoid grapefruit juice, as it may interfere with the drug’s metabolism
- Monitor liver function tests regularly during prolonged use
Precautions and Side Effects
Common side effects of Tolvaptan 15mg include increased urination, thirst, dry mouth, and weakness. Serious but rare risks include liver toxicity, dehydration, and electrolyte imbalance. It should not be used in patients with anuria or significant liver impairment unless strictly supervised.
Regular blood tests are necessary to monitor sodium levels, liver enzymes, and kidney function during treatment.
Who Should Not Use Tolvaptan?
- Patients with known hypersensitivity to Tolvaptan
- People with liver disease unless carefully monitored
- Individuals unable to sense or respond to thirst
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FAQs About Tolvaptan Tablets 15mg
Can Tolvaptan be used long-term?
Yes, under medical supervision, especially in ADPKD. Liver function must be monitored regularly.
Is Tolvaptan safe for elderly patients?
Yes, but dosage adjustments and monitoring are required to prevent dehydration and electrolyte imbalance.
How soon does Tolvaptan start working?
It begins increasing urine output and correcting sodium levels within 4–8 hours of the first dose.
