Description
Afatinib 20 mg – Targeted Therapy for NSCLC
Afatinib 20 mg is a prescription medication used in the treatment of advanced or metastatic non-small cell lung cancer (NSCLC) that carries specific genetic mutations. As a second-generation tyrosine kinase inhibitor (TKI), Afatinib blocks the action of proteins that promote cancer cell growth. It is often recommended as a first-line treatment for patients with epidermal growth factor receptor (EGFR) mutations.
What Is Afatinib 20 mg?
Afatinib is a cancer-fighting medication that targets specific genetic drivers of NSCLC. It is marketed under the brand name Gilotrif in many regions. This medication is particularly effective in treating cancers with EGFR mutations, such as exon 19 deletions or exon 21 (L858R) substitution mutations.
Afatinib 20 mg tablets are used as part of a daily oral treatment plan, and are usually continued until disease progression or intolerable toxicity occurs.
How Afatinib Works
Afatinib belongs to a class of drugs known as tyrosine kinase inhibitors (TKIs). It works by irreversibly binding to and blocking the activity of the EGFR and other related kinases. These receptors are often overactive in cancer cells and drive their rapid growth. By targeting and inhibiting these proteins, Afatinib slows or halts tumor progression.
This targeted mechanism makes Afatinib more effective and better tolerated compared to traditional chemotherapy in patients with EGFR mutations.
Key Benefits of Afatinib 20 mg
- Targeted treatment for EGFR-positive NSCLC
- Oral tablet – convenient daily dosing
- Second-generation TKI with broader inhibition range
- Delays progression of metastatic lung cancer
- May reduce tumor size and improve quality of life
Afatinib is often favored due to its irreversible binding mechanism and activity against multiple members of the ErbB family of receptors.
How to Take Afatinib 20 mg
Dosage: The usual starting dose is 40 mg once daily, but in some cases, doctors may adjust the dose to 20 mg or 30 mg based on tolerance or side effects. Follow your doctor’s instructions strictly.
Administration:
- Take the tablet on an empty stomach, at least 1 hour before or 2 hours after a meal
- Swallow whole with water – do not crush or chew
- Take at the same time each day
Do not stop treatment unless advised by your healthcare provider.
Precautions & Side Effects
Before starting Afatinib 20 mg, inform your doctor about your medical history, especially:
- Heart problems
- Kidney or liver disease
- Eye disorders or vision changes
- Skin sensitivity or rash
Possible Side Effects:
- Diarrhea
- Skin rash or dryness
- Mouth ulcers
- Weight loss
- Nail disorders
Some side effects may require supportive treatment or dose adjustments. Always consult your oncologist if symptoms worsen.
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