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Low Dose Naltrexone (LDN) 1.5 mg vs 3 mg – What’s Right for You?

What is Low Dose Naltrexone (LDN)?

Low Dose Naltrexone, commonly known as LDN, refers to daily doses between 1.5 mg and 4.5 mg of Naltrexone – a medication originally approved to treat opioid addiction. At low doses, however, LDN works very differently by modulating the immune system and reducing inflammation without affecting opioid receptors significantly.

How Does LDN Work?

LDN temporarily blocks opioid receptors for a short time each night. This causes the body to increase endorphin production, which improves immune function and reduces inflammation. This unique mechanism has shown promise in a variety of chronic and autoimmune conditions.

Conditions Treated with LDN

LDN is being increasingly used off-label for:

  • ✔️ Multiple Sclerosis (MS)
  • ✔️ Fibromyalgia
  • ✔️ Crohn’s Disease and IBS
  • ✔️ Hashimoto’s Thyroiditis
  • ✔️ Rheumatoid Arthritis
  • ✔️ Chronic Pain and Inflammation
  • ✔️ Lyme Disease and Long COVID

LDN 1.5 mg vs 3 mg – Which Strength is Right for You?

Feature LDN 1.5 mg LDN 3 mg
Recommended for Beginners / Sensitive patients Intermediate users / Maintenance
Dose frequency Once daily (at night) Once daily (at night)
Common use cases Autoimmune flares, titration start Stable chronic inflammation control
Adjustment Start with 1.5 mg and increase May increase to 4.5 mg if tolerated

Key Benefits of Low Dose Naltrexone

  • 💊 Reduces chronic inflammation
  • 🧠 Supports mental clarity and mood
  • 💪 Boosts immune response
  • 🌿 Non-addictive and well tolerated
  • ⚕️ Used in both autoimmune and neurodegenerative conditions

Side Effects

LDN is generally safe, but some people may experience:

  • Sleep disturbances or vivid dreams (often temporary)
  • Headache or mild nausea
  • Fatigue in early weeks

Always start at a low dose and follow your healthcare provider’s instructions for titration.

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FAQs – Low Dose Naltrexone (LDN)

Is LDN addictive?

No, LDN is non-addictive and does not produce a high. It works by modulating the immune system.

Can I take LDN with other medications?

Yes, but consult your doctor—especially if you’re taking opioids or immune-modulating drugs.

How long does it take for LDN to work?

Many people notice improvements within 4–6 weeks, but full effects can take 2–3 months.

Can I start directly with 3 mg?

It’s usually best to start with 1.5 mg and slowly increase based on tolerance and effect.