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Flagyl 400 mg: Powerful Metronidazole for Treating Infections

What is Flagyl 400 mg?

Flagyl 400 mg contains metronidazole, a potent antimicrobial medication aimed at treating a variety of anaerobic bacterial and protozoal infections. This higher-dose tablet is commonly prescribed when standard doses are insufficient or quicker resolution is needed.

How It Works

Metronidazole enters microbial cells and disrupts DNA structure, inhibiting replication and causing cell death. Its mechanism is particularly effective against anaerobic organisms and protozoa.

Medical Uses

Flagyl 400 mg is used to treat:

  • ✅ Severe bacterial vaginosis and pelvic infections
  • ✅ Trichomoniasis and Giardia lamblia infections
  • ✅ Anaerobic intra-abdominal or dental infections
  • ✅ Clostridioides difficile-associated diarrhea
  • ✅ Prophylaxis in colorectal surgery

Dosage & Administration

Typical adult dosage:

  • 400 mg orally every 8 hours for 7–14 days, depending on infection severity

Use with food or water to minimize stomach upset. Finish the full course even if symptoms improve early.

Side Effects & Precautions

Common side effects:

  • Nausea, metallic taste
  • Dizziness, headache
  • Abdominal discomfort, dark urine

Serious caution:

  • Allergic rash or swelling
  • Neurological symptoms like seizures or neuropathy
  • Severe diarrhea or blood in stool

Important precautions:

  • Avoid alcohol during treatment and for 48 hours afterward (can cause severe reactions)
  • Caution in pregnancy (first trimester) and breastfeeding: consult a doctor

Drug Interactions

Flagyl may interact with:

  • Warfarin—can increase bleeding risk
  • Alcohol—leads to flushing, vomiting, rapid heart rate
  • CYP3A4-affecting drugs—modify dosage of metronidazole

Always inform your healthcare provider about all medications and supplements you’re taking.

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Frequently Asked Questions

Can I drink alcohol while on Flagyl?

No. Drinking alcohol during treatment and for 48 hours after can cause severe adverse effects.

When will I feel better?

Symptoms often improve within 48–72 hours, but complete the course as prescribed.

Is Flagyl 400 mg safe during pregnancy?

Consult your doctor. It’s typically avoided in the first trimester unless necessary.

Can children use Flagyl 400 mg?

Use only with pediatrician’s supervision and weight-based dosing.

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