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Feravir 400 mg (Sofosbuvir): Potent Direct-Acting Antiviral for Hepatitis C

What is Feravir 400 mg?

Feravir 400 mg is an advanced antiviral tablet composed of sofosbuvir, a direct-acting antiviral (DAA) agent used in the treatment of chronic hepatitis C virus (HCV) infections. This high-strength tablet enables single-dose administration, simplifying treatment without the need for splitting tablets.

How It Works

Sofosbuvir works by inhibiting the HCV RNA-dependent RNA polymerase (NS5B). By acting as a nucleotide chain terminator, it stops viral replication within the liver, significantly reducing viral load and contributing to sustained virological response (SVR), commonly referred to as a “cure.”

Indications

Feravir 400 mg is indicated for use in combination therapy for:

  • Chronic hepatitis C (all genotypes)
  • HCV/HIV co-infection under specialist care
  • Patients with compensated or decompensated cirrhosis
  • Patients who have failed previous interferon-based therapy or first-generation DAAs

Dosage & Administration

Standard dose: 400 mg once daily (one tablet), with or without food, for 12 weeks (or as per doctor’s prescription). Treatment duration may vary based on genotype, liver health, and whether it’s combined with agents like velpatasvir or ribavirin.

  • Take at the same time daily to maintain consistent blood levels
  • Avoid missing doses; adherence is crucial for achieving SVR
  • Do not break, crush, or chew tablets

Benefits

  • ✅ High cure rates (>95%) across most genotypes
  • ✅ Simplified single-tablet daily dosing
  • ✅ Oral therapy—no injections or hospital visits for INF
  • ✅ Good tolerability and minimal contraindications
  • ✅ Effective even in patients with compensated cirrhosis and HIV co-infection

Side Effects & Safety

Feravir 400 mg is generally well tolerated; common side effects include:

  • Fatigue
  • Headache
  • Nausea
  • Insomnia or irritability

When combined with ribavirin, monitor for:

  • Anemia
  • Skin rash

Precautions:

  • Assess liver and kidney function at baseline and periodically
  • Screen for drug interactions (e.g., rifampicin, St. John’s wort)
  • Not recommended during pregnancy unless companion drug is safe

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Frequently Asked Questions

Can Feravir 400 mg be used alone?

No—sofosbuvir requires combination with other DAAs (like velpatasvir, ledipasvir, or daclatasvir) to achieve optimal cure rates.

How long should treatment last?

Most regimens require 12 weeks, but some genotypes and patient profiles may need 8 or 24 weeks per clinical guidelines.

Is Feravir effective for all genotypes?

Yes—with proper companion drugs, Feravir offers pan-genotypic treatment effectiveness.

Are there major drug interactions?

Avoid inducers of P-gp and CYP (e.g., rifampicin, carbamazepine, St. John’s wort)—consult your doctor before combining.