Enzalutamide 40 mg: Advanced Oral Therapy for Prostate Cancer Control
Table of Contents
What is Enzalutamide 40 mg?
Enzalutamide 40 mg is an oral medication categorized as an androgen receptor inhibitor, used primarily in the treatment of advanced or metastatic prostate cancer. Developed following the success of Xtandi®, this generic form provides a cost-effective and accessible alternative for patients undergoing hormone-based cancer therapy.
This 40 mg capsule strength allows for flexible dosing and easier titration based on tolerance and treatment response.
How Enzalutamide Works
Enzalutamide targets the androgen receptor pathway—a critical driver of prostate cancer. It:
- 🔒 Blocks receptor activation by testosterone and DHT
- 🛡️ Prevents receptor from moving to cell nucleus
- ⛔ Stops its binding to DNA, halting cancer-promoting gene expression
By interrupting the androgen signaling cycle, Enzalutamide slows tumor growth and progression, enhancing patient survival and quality of life.
Medical Uses & Indications
Enzalutamide 40 mg is prescribed for:
- Advanced or metastatic castration‑resistant prostate cancer (mCRPC)
- Non‑metastatic castration‑resistant prostate cancer (nmCRPC) to delay metastasis
- Combination with androgen‑deprivation therapy (ADT) or surgical castration
Before initiating therapy, doctors monitor PSA levels and imaging to assess disease status and adjust treatment accordingly.
Dosage & Administration
Standard Adult Dose: 40 mg capsule once daily, with or without food.
- Typical total dose: 160 mg/day (four capsules)
- Dosing adjustments may be made for side effects or drug interactions
- Do not crush or chew—swallow capsules whole with water
Important: Maintain concurrent androgen-deprivation therapy unless contraindicated.
Side Effects & Precautions
Enzalutamide 40 mg is well tolerated, but side effects include:
- Fatigue, hot flashes, muscle aches
- Hypertension or fluid retention
- Dizziness or mild headache
- Rare: seizure, falls, or cognitive changes
Warnings:
- Seizure risk—avoid in patients with seizure disorder or head trauma
- Monitor blood pressure regularly
- Use caution with other CNS depressants
- Avoid during pregnancy or breastfeeding
Regular check-ups, including blood testing (liver function, PSA, CBC), and blood pressure monitoring are essential during treatment.
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Frequently Asked Questions
How long does it take to work?
PSA levels usually drop within 4–12 weeks, with clinical improvement observed over months.
Can I take Enzalutamide with food?
Yes, it can be taken with or without food. Absorption is not affected by meals.
What dose do I take if experiencing side effects?
Your oncologist may reduce to 120 mg daily or manage symptoms; consult before adjusting.
Is generic as effective as Xtandi (brand)?
Yes. Generic Enzalutamide has the same active ingredient, safety profile, and efficacy as brand-name Xtandi.