Apixaban Tablets 2.5 mg vs 5 mg: Key Differences, Uses & Safety Guide
Table of Contents
What is Apixaban?
Apixaban is a prescription blood thinner (anticoagulant) used to treat and prevent blood clots. It works by inhibiting Factor Xa, reducing the formation of harmful clots. Apixaban is commonly prescribed for atrial fibrillation (AFib), deep vein thrombosis (DVT), pulmonary embolism (PE), and clot prevention after surgery.
Apixaban 2.5 mg vs 5 mg: At a Glance
| Feature | Apixaban 2.5 mg | Apixaban 5 mg |
|---|---|---|
| Use | Maintenance, reduced dose | Standard treatment dose |
| Prescribed For | Older, underweight, kidney-impaired patients | General adult population |
| Frequency | Twice daily | Twice daily |
| Monitoring | No INR monitoring needed | No INR monitoring needed |
| Typical Duration | Extended prevention phase | Initial and active treatment phase |
When is Apixaban 5 mg Used?
Apixaban 5 mg is the standard full-strength dosage and is prescribed for:
- Stroke prevention in atrial fibrillation
- Treatment of active DVT and PE
- Ongoing prevention of clot recurrence
It is typically used in adults who do not meet criteria for a dose reduction.
When is Apixaban 2.5 mg Used?
Apixaban 2.5 mg is prescribed for:
- Patients aged ≥ 80 years
- Body weight ≤ 60 kg
- Serum creatinine ≥ 1.5 mg/dL
It’s also used for long-term maintenance therapy after the first 6 months of DVT/PE treatment.
Dosage Schedules
Standard Apixaban dosing based on condition:
- Atrial Fibrillation: 5 mg twice daily; 2.5 mg if two or more dose-reduction criteria are met
- DVT/PE Treatment: Start with 10 mg twice daily × 7 days, then 5 mg twice daily
- Maintenance (After 6 Months): 2.5 mg twice daily
Side Effects and Safety
Common side effects:
- Bruising or minor bleeding
- Nosebleeds or bleeding gums
- Fatigue or dizziness
Serious risks:
- Internal bleeding
- Blood in stool or urine
- Severe headaches (possible brain bleed)
Apixaban is generally safer than warfarin, with lower rates of intracranial bleeding.
Which Dose is Right for You?
Your healthcare provider will determine the correct dose based on your:
- Age
- Weight
- Kidney function
- Treatment goals (prevention vs. active treatment)
Do not switch dosages on your own. Always follow professional medical guidance.
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FAQs About Apixaban Doses
What is the difference between Apixaban 2.5 mg and 5 mg?
5 mg is the standard full-strength dose, while 2.5 mg is used for dose reduction or extended maintenance in certain patients.
Can I switch between Apixaban doses?
No. Always consult your doctor before adjusting your Apixaban dosage.
Is Apixaban safer than warfarin?
Yes. Apixaban has fewer food and drug interactions, no need for INR monitoring, and lower risk of brain bleeding.
Can elderly patients take Apixaban?
Yes. The 2.5 mg dose is commonly prescribed for older adults or those with kidney issues.
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