Description

Ibrutinib 140 mg Capsules – Targeted BTK Inhibitor for CLL, MCL, and WM

Ibrutinib 140 mg is a targeted oral cancer therapy used in the treatment of various types of blood cancers. It belongs to a class of drugs known as Bruton’s tyrosine kinase (BTK) inhibitors, which work by blocking abnormal signaling in cancerous B cells. Ibrutinib is primarily used to treat Chronic Lymphocytic Leukemia (CLL), Mantle Cell Lymphoma (MCL), Waldenström’s Macroglobulinemia (WM), and other B-cell malignancies.

Manufactured under strict clinical standards, Ibrutinib 140 mg offers an effective oral chemotherapy option, allowing many patients to avoid more intensive intravenous therapies. It helps slow or stop the growth of cancer cells and is often used in long-term management of relapsed or treatment-resistant lymphomas and leukemias.

What Is Ibrutinib 140 mg Used For?

Ibrutinib 140 mg is indicated for the treatment of:

• Chronic Lymphocytic Leukemia (CLL): With or without 17p deletion
• Mantle Cell Lymphoma (MCL): In patients who have received at least one prior therapy
• Waldenström’s Macroglobulinemia (WM): A rare type of non-Hodgkin lymphoma
• Marginal Zone Lymphoma (MZL): After prior anti-CD20 therapy
• Chronic Graft vs Host Disease (cGVHD): After failure of systemic therapy

How Ibrutinib 140 mg Works

Ibrutinib selectively binds to and inhibits the Bruton’s tyrosine kinase (BTK) enzyme. BTK plays a crucial role in the B-cell receptor signaling pathway, which is essential for B-cell survival and proliferation. By inhibiting BTK, Ibrutinib interrupts the survival signals in malignant B cells, causing cancer cell death and reducing tumor progression.

Mechanism Highlights:

• Blocks BTK activity in B-cell lymphomas
• Prevents cancer cell survival and proliferation
• Reduces tumor load and improves overall survival

Ibrutinib Dosage and Administration

Ibrutinib 140 mg is taken orally once daily. Dosage is determined by the specific condition:

• CLL/WM: 420 mg daily (usually 3 x 140 mg capsules)
• MCL/MZL: 560 mg daily (4 x 140 mg capsules)
• cGVHD: 420 mg daily

Swallow capsules whole with water. Do not crush or chew. Take at the same time each day. Dosage may be adjusted based on tolerance and side effects.

Benefits of Ibrutinib 140 mg

• Convenient once-daily oral treatment
• Targeted therapy with high response rates
• Improves survival and reduces disease progression
• Effective even in patients with 17p deletion in CLL

Side Effects of Ibrutinib

Common side effects:

• Diarrhea
• Fatigue
• Muscle and joint pain
• Nausea
• Bruising or minor bleeding

Serious side effects (seek immediate medical attention):

• Major bleeding (intracranial or gastrointestinal)
• Cardiac arrhythmia (atrial fibrillation)
• High blood pressure
• Infections (especially respiratory)
• Cytopenia (low blood cell counts)

Monitoring: Blood counts, liver enzymes, ECG (for arrhythmia), and infection symptoms should be regularly monitored during treatment.

Precautions and Warnings

• Avoid grapefruit or Seville orange juice (CYP3A inhibitors)
• Use with caution in patients with heart or bleeding disorders
• Women should avoid pregnancy during and 1 month after treatment
• May interact with antifungals, antibiotics, antivirals, and anticoagulants

Drug Interactions

Inform your doctor if you’re using:

• Ketoconazole, ritonavir, clarithromycin (CYP3A inhibitors)
• Carbamazepine, phenytoin, rifampin (CYP3A inducers)
• Anticoagulants and antiplatelets (increased bleeding risk)

Storage Instructions

• Store at 20–25°C (68–77°F)
• Keep away from moisture and heat
• Keep out of reach of children

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Conclusion

Ibrutinib 140 mg Capsules are a breakthrough in oral cancer treatment, especially for patients with chronic lymphocytic leukemia and other B-cell malignancies. With proper medical supervision, it helps reduce tumor burden and improve quality of life. Always consult a specialist for personalized treatment and monitoring.